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Genetic instability of modified stem cells – a first step towards malignant transformation?
Am J Stem Cells. 2013 Mar 8;2(1):39-51. Print 2013. doi:
Steinemann D, Göhring G, Schlegelberger B
Abstract:
.....This review intends to comprehensively summarize the current knowledge on genetic instability of embryonic and iPSCs, with an emphasis on cytogenetic alterations, and compares these data with what is known from tumorigenesis.
PMID: 23671815
Free Full-Text: http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23671815/