Aged Stem Cells and Niches Rejuvenated by Systemic Factors; Implications for WILT
Haematopoietic stem cells (HSC) exhibit a range of functional declines during biological aging. There has been comparatively little exploration of the possibility of outside causes for age-related HSC dysfunctions, such as the role of age-related shifts in the systemic and local environment and the aging of the bone marrow niche. In a recent report, Dr. Amy Wagers’ group have demonstrated the reality – and the reversibility – of both of these influences on age-related HSC dysfunction.
