SENS6: Reimagine Aging Conference

Our SENS6: Reimagine Aging Conference, which ran from September 3 – 7, 2013 at the University of Cambridge featured talks from many of the world’s most renowned researchers in regenerative medicine and aging. Here you can view an overview of the conference as well as selected presentations and interviews. Please check back from time to time as we continue to add new videos.

SENS6: Reimagine Aging Conference Video

The SENS6: Reimage Aging Conference in September of 2013 marked the sixth conference held at historic Queens’ College at the University of Cambridge. World-renowned scientists and other visionaries in the field of regenerative medicine presented the latest cutting-edge advances in regenerative medicine and biotechnology. See why many remarked that it was the best SENS Conference to date.

SRF CEO Mike Kope highlights the buzz and importance of SENS6

In this interview, SENS Research Foundation President and CEO Mike Kope describes the buzz the SENS6: Reimagine Aging Conference generated among its attendees and discusses the organization’s future.

SRF CSO Dr. Aubrey de Grey discusses SENS6 and key achievements of SRF to date

In this interview, Dr. Aubrey de Grey, SENS Research Foundation's Chief Science Officer, talks about SENS6 and the ever-increasing impact of the SENS Conference series.

Reimagine Aging - SRF CEO Mike Kope

Mike Kope, President and CEO of SENS Research Foundation, delivers his SENS6 presentation in this video. He showcases SRF’s new messaging materials and discusses the organization’s mission and strategies.

Monkeying around with calorie restriction: is a calorie a calorie? - Donald Ingram

In the first talk of the SENS6 conference, Donald Ingram reports on the health benefits, but lack of longevity enhancement, observed during NIA's primate calorie restriction study.

Impact of CR on aging in rhesus monkeys – a focus on metabolism - Rozalyn Anderson

Rozalyn Anderson reviews lifespan and metabolic data from the University of Wisconsin-Madison's primate calorie restriction study.

Outcomes from parallel CR monkey studies at NIA and UW Madison - Donald Ingram/Rozalyn Anderson

Donald Ingram and Rozalyn Anderson jointly present an analysis of the similarities and differences between the NIA and UW-Madison primate calorie restriction studies.

Sirtuin regulation of metabolism and stem cells - Danica Chen

Danica Chen discusses the role of sirtuins in aging, focusing on SIRT3, its role in stem cell maintenance and its decline with age.

Telomere dysfunction and stem cell aging - Zhenyu Ju

Zhenyu Ju reviews the complex relationship between the maintenance of telomere length, stem cell function and ageing-related disease.

ALTered cancer cells: Uncovering the genetic basis of ALT (Alternative Lengthening of Telomeres) - Haroldo Silva

Dr. Haroldo Silva explains the alternative lengthening of telomeres (ALT) mechanism and describes significant progress made to develop ALT assays amenable to high-content/high-throughput screens. David Halvorsen then describes a study of the role of a protein called POT1 in this elusive mechanism.

Apheresis of inhibitors of TNF disrupts tumor immunoevasion - Rigdon Lentz

Rigdon Lentz explains how tumours use secreted cytokine receptors to avoid destruction by the immune system, and presents exciting data on the efficacy of a therapy designed to disrupt this defence.

Nanoparticle-based artificial RNA silencing machinery for antiviral therapy - Charles Cao

Charles Cao presents data on a class of highly stable, selective and non-toxic cell-penetrating nanoparticles that effectively induce RNA interference in human cells.

PANACEA broad-spectrum antiviral therapeutics - Todd Rider

MIT's Dr. Todd Rider introduces the PANACEA program, aimed at developing very broad-spectrum antimicrobial agents, and particularly discusses DRACO - a protein that effectively triggers apoptosis in cells containing viral DNA of any variety.

Effect of senescence on bone remodelling: the role of inflammageing - Lia Ginaldi

Lia Ginaldi discusses the role of age-related chronic inflammation in modifying the behaviour of osteoblast and osteoclast activity in elderly patients, contributing to senile osteoporosis.

Chromatin and epigenetic dynamics in senescence phenotypes - John Sedivy

John Sedivy reviews the changes in chromatin organization that occur during cellular senescence, and the resulting increase in the activation of mutagenic retrotransposable elements (RTEs).

Targeting the senescence-associated secretory phenotype - Kevin Perrott

Kevin Perrott explains that the loss of tissue homeostasis with age is accompanied by a low but detectable rise in pro-inflammatory factors. He offers evidence that the senescence-associated secretory phenotype (SASP) may play a role in this phenomenon. A screen to identify candidate compounds able to mitigate the SASP yielded the flavonoid Apigenin, which he discusses in greater detail.

Accelerating synthetic biology in Europe - Bill Liao

Entrepreneur and SENS Research Foundation board member Bill Liao discusses the potential for angel investors to accelerate critical biotechnical research overlooked by mainstream funding bodies.

Pathways to Progress - Sara Lightowlers

Sara Lightowlers presents the conclusions of a round-table meeting on the barriers to market entry encountered by new drugs, and approaches that could be taken to provide patients with access to badly-needed therapies while clinical trials are still in progress.

Accelerating translational research processes from bench to clinic - Richard Barker

Richard Barker, the Director of the Centre for the Advancement of Sustainable Medical Innovation (CASMI), explains how CASMI plans to restore waning funder confidence in medical innovation by using testable models for change.

Redefining and reversing death: what has resuscitation science taught us about death and what happens when we die? - Sam Parnia

Sam Parnia discusses the state of the art in resuscitation science, presenting uncomfortable evidence that many patients are being "left for dead" long before their demise is truly irreversible.

Low risk for coronary artery disease and findings in the TERC region on 3q26 - Elizabeth Corder

Elizabeth Corder discusses the presence of specific genetic patterns in the vicinity of the telomerase gene and their association with heart disease and longevity.

Innate and vaccine-generated antibodies against transthyretin amyloids - Brian O'Nuallain

The accumulation of extracellular amyloid aggregates leads to a variety of age-related diseases. Brain O’Nuallain explains his lab’s investigation into the therapeutic and diagnostic potential of innate and vaccine-generated antibodies that target toxic amyloid assemblies of a blood transport protein, transthyretin, the cause of senile systemic amyloidosis.

Utilizing B cells to recreate the biochemical environment of youth - Matthew Scholz

Immusoft CEO Matthew Scholz presents their technology employing modified B cells to deliver protein therapeutics directly to the body, greatly simplifying their chronic administration.

Myelin regeneration and ageing - Robin Franklin

Cambridge's Robin Franklin reviews the mechanism and regulation of remyelination, its deterioration in ageing, and prospective therapeutic targets.

Regeneration in the adult organism - a cure for ageing? - Malcolm Maden

Malcolm Maden presents results on the signalling role of retinoic acid in salamander regeneration and its potential application in triggering regeneration in mammalian tissues, including lung and spinal cord.

SENS6 Keynote Presentation: Technologies for reading, writing & interpreting omes - George Church

In the SENS6 conference’s keynote address, Harvard’s Dr. George Church provides an exciting overview of genomics and outlines a bold vision for the future. During this video, Dr. Church describes recent advances in the field of genomics and in the reading, writing, and interpretation of “-omes” fields.

Sodium-potassium ATPase modulation for aging related disease - James Larrick

James Larrick discusses a new immunotherapeutic approach to heart failure, utilising a specific monoclonal antibody to the sodium-potassium pump NKA.

What good is an old brain in a young body – a strategy for regenerating the neocortex - Jean Hébert

Jean Hébert presents an approach to restoring lost neocortical tissue in elderly or traumatically injured patients by introducing highly migratory engineered stem cells.

Inducing exocytosis to remove lipofuscin - John Furber

John Furber reviews the role of lipofuscin in cellular ageing, and reports on the ongoing development of a novel exocytosis-stimulating therapy designed to clear lipofuscin from older post-mitotic cells.

Screening of medicinal plants in the Judea region (Israel) for geroprotective activities - Arie Budovsky

Arie Budovsky reviews a recent screen of plants growing in the Judea region in search of compounds having geroprotective properties.

Targeted mitochondrial therapeutics in aging - Rafal Smigrodzki

Gencia's Rafal Smigrodzki presents animal data demonstrating a rejuvenating effect observed when age-related mitochondrial suppression is relieved.

Rescue of mtDNA mutations by allotopic expression of engineered mitochondrial genes - Matthew O'Connor

Matthew O’Connor explains his research team’s efforts to enable mitochondria to continue to produce energy normally even after mitochondrial mutations have occurred, by engineering backup copies of the thirteen protein-coding mitochondrial genes in the nucleus.

Characterization of decellularized thymus scaffolds for use in engineering thymus tissue - John Jackson

Professor John Jackson explains the unique challenges of tissue-engineering a thymus, then shares results from his laboratory indicating that decellularized thymus scaffolds could be used as the foundation for newly engineered thymuses.

Ectopic organogenesis in lymph node - Eric Lagasse

Eric Lagasse explores the unique properties of the lymph node microenvironment, and presents recent data indicating its suitability as an "in vivo bioreactor" for tissue engineering.

Cardiovascular stressors induce lysosomal dysfunction, sirtuin-1 depletion and premature senescence of vascular endothelium - Michael Goligorsky

Michael Goligorsky reviews three distinct pathways leading to vascular/endothelial senescence, and introduces therapies designed to modulate each mechanism.

Strategies for the clearance of age-related lysosomal residuals: 7-ketocholesterol and foam cell formation - Jacques Mathieu

Dr. Jacques Mathieu introduces lysosomal storage diseases and reveals proof-of-concept results indicating that the selective removal of intra-lysosomal substances can help attenuate age-related disease.

Treating age-related macular degeneration through enhanced lysosomal degradation of A2E - Ghezal Beliakoff

Ghezal Beliakoff introduces SENS20, an enzyme with the potential to safely degrade a lipofuscin compound implicated in Age-Related Macular Degeneration (AMD), a leading cause of vision loss among individuals over sixty-five.

The Geroscience Interest Group (GSIG): tracing pathological consequences of fundamental aging processes - James Appleby

James Appleby, of the Gerontological Society of America, introduces a new trans-NIH initiative to identify and tackle the underlying biological causes of multiple age-related diseases.

Slovenia's bid for the world stage in biogerontology - Tanja Dominko

Tanja Dominko introduces the goals and strategy of Slovenia's new interdisciplinary ageing research centre, ICAR.

Why orthodox medicine must change - the need for preventative/regenerative medicine - Phil Micans

Phil Micans comments on problems developing with the current approach to late-life medical care, and identifies preventative, regenerative medicine as a more sensible therapeutic paradigm.

Dietary and Nutritional Manipulation of the Nuclear Transcription Factors, PPAR's and SREBP's, as a Tool for Reversing the Primary Diseases of Premature Death and Aging - Karen Kurtak

Karen Kurtak discusses the regenerative PPAR pathway and proposes that existing PPAR-activating drugs have fallen short of clinical expectations only due to an incompatibility with contemporary diets.

Healthy aging: how to stay bonny & transcend inflammation? - Patrizia d'Alessio

Patrizia d'Alessio discusses clinical results of natural dietary supplements beneficial in arthritis, and the potential for therapies that manipulate the gut microbiota to mitigate ageing-associated inflammation.

Klotho polymorphisms and longevity: a systematic review - Calogero Caruso

Calogero Caruso reviews associations between inherited polymorphisms in the Klotho gene and human longevity, and discusses the extended lifespan of transgenic mice over-expressing Klotho.

Insulin pathway and its correlation with ageing and age-related diseases - Giulia Accardi

Giulia Accardi discusses the insulin-mediated mechanisms underlying the observed correlation between type 2 diabetes and Alzheimer's disease.

Bioinformatic analysis of factors involved in age-related mineralization of soft tissues - Anastasia Shindyapina

Anastasia Shindyapina reviews the process of age-related calcification and its relevance to pathology, as well as potential therapeutic targets suggested by a novel bioinformatic analysis.

How does the body know how old it is? - Josh Mitteldorf

Josh Mitteldorf discusses the hypothesis that aged bodies retain a latent capacity for repair that might be reactivated by manipulating the molecular "clock" responsible for their repression.

Collective consequences of a very long life. The right to life extension could / should be considered a human right - Didier Coeurnelle

Didier Coeurnelle makes the social and moral case for state-subsidized life extension therapies.

On the history of life-extension research: Does the whole have parts? - Ilia Stambler

Ilia Stambler reviews the history of scientific life extension research in the last century, highlighting its role in driving biomedical innovation.

Towards priorities for aging research - Scott Needham

Scott Needham discusses quantitative methods for allocating biomedical and clinical research funding based on mortality data.

Legal problems of registering substances and therapies to cure aging - Daria Khaltourina

Daria Khaltourina considers the problems encountered when bringing to market therapies with potential anti-aging effects, but which are not targeted at a specific ICD-listed disease.

Aging, single-cell methylomes - Silvia Gravina

Dr. Silvia Gravina raises the question of how unstable the epigenome really is. She then introduces a procedure which will allow epigenomic drift to be analyzed via DNA methylation patterns in single cells.

New economic arguments for accelerating aging research - Alex Zhavoronkov

Alex Zhavoronkov presents a detailed economic and demographic analysis of the benefits of widespread extension of healthy, productive lifespans.

What reassurances do the community need regarding life extension? Evidence from studies of community attitudes and an analysis of film portrayals - Mair Underwood

Mair Underwood reviews portrayals of human lifespan extension in popular films, and suggests ways for biogerontologists to improve the public understanding and perception of the field.

International Futures: impact of decelerated or abolished aging on human demographic change - Randall Kuhn

Randall Kuhn models negligible senescence using the International Futures forecasting system, then discusses the demographic and social implications predicted to arise.

Understanding the paradox of opposition to long-term extension of the human lifespan: fear of death, cultural worldviews, and the illusion of objectivity - Thomas Pyszczynski

Thomas Pyszczynski introduces terror management theory, a psychological model which may explain the irrational opposition sometimes directed towards prospects of significantly longer lifespans.