September 11th 2016

September 11, 2016

SENS Research Foundation MitoSENS Team Publishes Paper in Nucleic Acids Research

We are delighted to announce that the SRF MitoSENS team has published a peer-reviewed paper entitled "Stable nuclear expression of ATP8 and ATP6 genes rescues a mtDNA Complex V null mutant", in the journal Nucleic Acids Research. This is a truly great example of your support at work, and what your contributions to fundraisers like last year's MitoSENS campaign can accomplish, along with generous contributions from groups like the Foster Foundation as well as your individual donations. So thank you very much from all of us here at SRF.

This groundbreaking work is both a significant contribution to mitochondrial research and a long-anticipated proof of concept of one of the key concepts of the SENS approach to repairing aging damage. For almost a decade the SENS Research Foundation has helped to fund and conduct research on the allotopic expression of mitochondrial genes, a way to both cure mitochondrial disease and prevent mitochondrial DNA damage from contributing to the degenerative aging process. Allotopic expression works by creating backup copies of important mitochondrial genes in the cell nucleus, altered so that the resulting proteins can make their way back to the mitochondria where they are needed. The full text of the paper is available online; you can read it here.

Your MitoSENS Questions Answered Tomorrow On Reddit



Join SRF CSO Aubrey de Grey and lead MitoSENS researcher Matthew O'Connor in a Reddit Ask Me Anything event tomorrow (Monday) at 11 AM PST / 2 PM EST / 6 PM GMT. If you have questions about SRF's groundbreaking work to fix mitochondrial dysfunction, The MitoSENS AMA is your chance to ask. Don't miss it!

Thank You! "Control ALT, Delete Cancer" Fundraising Goal Met -

Now Let's Make The Final 6 Days Count

As of Saturday, September 10, the OncoSENS fundraising campaign has raised a total of $62,545 -- not just meeting but exceeding the goal of $60,000! Thank you from all of us at SENS Research Foundation for making this goal happen - we are beyond grateful to all of you who share our commitment to ending cancer.

The campaign officially ends on September 17 -- so there is still time to help! Every additional dollar will allow us to perform even more testing of compounds from our drug library. Remember that aging is a multi-faceted problem, and that robust funding for each research strand is critical to making comprehensive rejuvenation therapies a reality. Please visit the page for details on the campaign.

Honor Your Loved One's Fight Against Cancer with a $30 Donation

If you're like most of us, you probably have a beloved family member, friend, or pet who has faced a cancer diagnosis. Honor their fight (whether they are now a survivor, or in memory) with a $30 donation to the "Control ALT, Delete Cancer" campaign between now and the end of the campaign on September 17, 2016. This will earn a spot for their photo in our Wall (demo image below), which will be on permanent display online and physically in our Research Center. 

SENS Research Foundation Cited in Nature

The extraordinary costs of drug development could be mitigated by adopting a less secretive approach in the early stages of research, according to a recent article in Nature - citing work published early this year by SRF Summer Scholar Zeeshan Arshad and co-authors including SRF-funded Ph.D. James Smith, SRF Director of Alliances David Brindley, as well as RB2015 keynote speaker Chas Bountra.
Following an example of what happened when a particular compound was made freely available, this article makes a powerful case for open access to knowledge and sharing among the research and academic community. This is yet another example of your donor dollars at work, making crucial research possible.

An Animated Introduction to SENS Science with Edward James Olmos

It has been several years in the making, but SENS Research Foundation is pleased to present the full set of eight introductory videos narrated by none other than Edward James Olmos! 

These short animated explanations are a great way to learn the basics of the seven types of aging damage SENS Research Foundation is targeting in our various research programs, and the damage-repair concept that ties it all together. Watch, listen, learn -- and be sure to share with your friends and family!

Individual Presentation Videos from the 2016 Rejuvenation Biotechnology Conference Now Online

You can now select and watch each individual presentation given at the RB2016 conference, held this year at the Buck Institute for Research on Aging in Novato, CA. Visit our RB2016 Conference Videos page to access these fascinating talks, on subjects ranging from the promise of mitochondrial peptides to implanted anti-cancer viruses to strategies for addressing regulatory hurdles.


You can also still watch the full sessions (including Q&A segments) at the following links:


Tuesday Session

Wednesday AM Session

Wednesday PM Session

VIDEO - Michael Greve at RB2016

SENS Research Foundation would like to once again extend our gratitude toward Michael Greve, an Internet enterpreneur who has become the first donor to SRF's new major Project|21 initiative. What would lead someone to put $10 million into SENS Research Foundation's work? Find out as Michael, in his talk for the 2016 Rejuvenation Biotechnology conference, relates his personal journey to investing in SRF, and discusses why SRF's new Project|21 initiative to push forward human clinical trials will be critical to the actualization of comprehensive rejuvenation medicine.

Michael Greve is the founder and CEO of the Forever Healthy Foundation, a non-profit organisation committed to educating people about the steps that can already be taken to mitigate the damaging effects of aging, and the CEO of Kizoo Technology Ventures, an investment company focusing on internet services and digital communication.



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