October 16th 2017

October 16, 2017

Dear Friend and Supporter of SENS Research Foundation,
Welcome to the SENS Research Foundation Year End Fundraising Campaign Newsletter. We wanted to take this opportunity to thank all of you for your support for SENS Research Foundation. The last 12 months have been very exciting -- and we’ll be telling you about all of it in the coming weeks. 

In this newsletter, we’re sharing the latest updates on our new research program launch -- an exciting step forward made possible by your support. Please consider contributing to our year-end campaigns -- by doing so, you enable us to continue our critical work toward real cures for age-related disease.

Thank you,

The SENS Research Foundation Team

 SENS Research Foundation Launches 2017 Year End Campaign

SENS Research Foundation’s year-end fundraising goal this year is $250,000. Your contributions to this campaign are critical for SENS Research Foundation's financial health. We use these year-end donations to support our research programs both at the SENS Research Foundation Research Center in Mountain View, as well as our programs at Yale, the Buck Institute, the Babraham Institute, and Oxford.

This year, we’re doing something a little different in order to show our appreciation for our donors. If you contribute $250 or more between October 15th and December 31st, you will receive a SENS Research Foundation t-shirt just like the ones worn by our team. Donate $500 or more, and you will receive a SENS Research Foundation Polo shirt. Donations should be made by check, Paypal, stock, or Bitcoin. Donors will be contacted for their shipping address after the donation is received. Limit 1 shirt per donor. Shirts are available in unisex Small, Medium, Large, XL and XXL. 

Black t shirt with SRF logo (left),black polo shirt with SRF logo (right)

Please help us reach our $250,000 goal by donating generously today! Remember, your support is crucial to our continued fight against age-related disease. Anyone interested in offering a challenge grant for Giving Tuesday – November 28th – please contact Jerri.Barrett@sens.org.

2017 Fight Aging! Year End Campaign:

Become an SRF Patron and Your Donation will be Matched All Year

This year Fight Aging! asks you to consider joining the ranks of the SRF Patrons, a special group of supporters willing to take the next step in their commitment to fighting age-related disease. To become a Patron, simply sign up for a recurring monthly donation to SENS Research Foundation, and then keep your regular contributions going until the job is done and the first rejuvenation therapies are deployed. It's easy, it's tax-deductible, and as a nonprofit organization, SRF relies on not just large sporadic donations (though we definitely always appreciate those!), but on having a consistent income stream to support day-to-day operations in the service of research, education, and outreach. Patrons will be eligible for the T-shirt award as well*.

As an incentive, Fight Aging! will match the donations of anyone who signs up as a monthly donor between October 15th and December 31st, up to $3000 per month. Our thanks to Reason, Josh Triplett, and Christophe Cornuejols for providing this funding. You can follow our progress at the SRF website. To set up your monthly donation subscription, go to SRF's donate page.

* Limit 1 shirt per donor

SENS Research Foundation Announces New Research Program on Developing Monoclonal Antibodies Against Glucosepane with David Spiegel Lab

MOUNTAIN VIEW, Calif. —September 18, 2017 — SENS Research Foundation (SRF) has launched a new research program focused on developing monoclonal antibodies against glucosepane. David A. Spiegel, MD, PhD is Professor of Chemistry and Pharmacology at Yale University, and will be running the project in his laboratory, which focuses on developing new methods and molecules that will facilitate our understanding and treatment of human disease.

Glucosepane is the most prevalent crosslink found in collagen in people over 65 years of age, and its presence has been correlated to age-related tissue damage through various mechanisms. Understanding of glucosepane has been hampered by the molecule’s complex and sensitive chemical structure; it can only be isolated from human samples in minute quantities and in an impure form. To enable these advances in both basic and therapeutic science, the Spiegel laboratory has recently accomplished the first total synthesis of glucosepane. The lab is now utilizing its novel synthetic glucosepane derivatives to generate the first monoclonal anti-glucosepane antibodies. Access to these antibodies would profoundly enable and accelerate the goal of developing the first anti-glucosepane monoclonal antibodies, while consequently bringing closer the obtainment of the first discrete, specific reagents for labeling, studying, and perhaps also cleaving glucosepane in vivo. Such tools have tremendous potential to help illuminate, and reverse, age-related damage as it occurs in human tissues.

“Our collaboration with SRF has significantly increased our understanding of glucosepane and the impact it has on our tissues as we age. I am very pleased to continue collaborating with SENS Research Foundation,” said Dr. Spiegel.

“Launching our new project with David Spiegel will enable SRF to continue to build on the momentum which was created by his initial project which resulted in his ability to synthesize glucosepane. Now we are able to move forward in the creation of potential treatments for age-related damage in human tissue,” said Dr. Aubrey de Grey, CSO, SENS Research Foundation.

This research has been made possible through the generous support of Michael Antonov and the Forever Healthy Foundation, and its founder Michael Greve. The Forever Healthy Foundation is a private nonprofit initiative whose mission is to enable people to vastly extend their healthy lifespans and be part of the first generation to cure aging. In order to accelerate the development of therapies to bring aging under full medical control, the Forever Healthy Foundation directly supports cutting-edge research aimed at the molecular and cellular repair of damage caused by the aging process.

Undoing Aging 2018 Announces Speaker Dr. James L Kirkland

Dr. James L. Kirkland will be speaking at the Undoing Aging 2018 conference to be held in Berlin, Germany, March 15-17, 2018. James L. Kirkland, M.D., Ph.D., is the director of the Robert and Arlene Kogod Center on Aging at Mayo Clinic and Noaber Foundation Professor of Aging Research.

Dr. Kirkland’s research is on cellular senescence, age-related adipose tissue and metabolic dysfunction, and development of agents and strategies for targeting fundamental aging mechanisms to treat age-related chronic diseases and disabilities. He published the first article about drugs that clear senescent cells – senolytic agents.

Three Minutes. Four People. One Top-Rated Nonprofit Award.

Will You Help SRF?

If you support SENS Research Foundation's work toward real cures for age-related disease -- tell the world! Right now, we need just four more five-star ratings before October 31 to achieve Top-Rated Nonprofit status. GreatNonprofits – the #1 source of nonprofit stories and feedback – is honoring highly regarded nonprofits with their 2017 Top-Rated List. Won’t you help us raise visibility for our work by posting a brief story of your experience with us? All content will be visible to potential donors and volunteers. It’s easy and only takes 3 minutes. Go here to get started.

Bitcoin Update

Thank you to all of our Bitcoin Donors for your generous support of the SENS Research Foundation. Please note that we have switched our Bitcoin activity from Coinbase to BitPay. To make a Bitcoin donation, please go to our Donate page

Where in the World is Aubrey de Grey?

Dr. Aubrey de Grey will be speaking at the following events:

Where: Royal Danish Opera, Copenhagen, Denmark
When: October 23, 2017
From the SingularityU Denmark website: "This October you can meet Singularity University’s world-leading experts for the first time in Scandinavia at the SingularityU Denmark Summit. Join more than a thousand Scandinavian doers, thinkers, leaders, innovators, entrepreneurs, investors, students and executives for an intensive two-day deep dive into Our Exponential Future."

Where: Boston, Massachusets, USA
When: October 27, 2017

[The] 2017 Connected Health Conference brings together the highly regarded Partners Connected Health Symposium and the PCHAlliance Connected Health Conference (formerly the mHealth Summit), to create the preeminent leadership gathering focused on the rapidly expanding field of technology-enabled health and wellness. 

Where: Kuala Lumpur, Malaysia
When: November 4, 2017

From the iCapital website: "A key objective of the 2017 Global Investor Week is to allow the participants to critically re-examine and discuss fundamental truths and assumptions about life, economics, and investments, and to arrive at new findings and conclusions. The many talks delivered by a good array of speakers on Saturday and Sunday, 4th and 5th November, will advise participants on how and what can be done for one to benefit from these new discoveries, which have been arrived at based on careful and thorough research and analysis."



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