October 16th 2015 - Special Edition: SENS Research Foundation Making News

October 16, 2015


New Synthetic Process Developed at Yale University Will Allow Scientists to Examine a Critical Link Associated with Diabetes, Inflammation and Human Aging
MOUNTAIN VIEW, Calif. — October 15, 2015 — A new study funded by the SENS Research Foundation sheds greater light on diabetes and aging through a synthetic process developed at Yale University. The new process will allow researchers to study glucosepane, a key molecule involved in diabetes, inflammation, and human aging.
Glucosepane is considered to be a critical chemical link in both diabetes and aging. It is also an independent risk factor for long-term microvascular complications in diabetes. In an article published this week in the journal Science, senior author David Spiegel and his colleagues describe the new synthesis, as well as a new synthetic methodology, which may have applications beyond the current research.
Spiegel, a professor of chemistry and pharmacology at Yale, says that with access to synthetic glucosepane, scientists will now be able to generate tools to examine the role this molecule plays in human health and perhaps, develop molecules to inhibit or reverse its formation.
Glucosepane contains a rare isomer of imidazole, which has never before been observed in natural molecules, other than those in the glucosepane family. Spiegel and his colleagues developed a new methodology for synthesizing this imidazole form that requires only eight steps.
"We are extremely proud to have supported this project and the developments leading to better insights on diabetes and aging," said Mike Kope, CEO, SENS Research Foundation. "To have Science recognize the accomplishment of Dr. Spiegel and his team doesn't just demonstrate the value of our contribution to medical research; it helps raise awareness that the SENS Research Foundation approach can lead to better insights about aging and age related disease."
The first author of the study is Cristian Draghici, a former postdoctoral researcher at Yale who is now at the Broad Institute of MIT and Harvard. Tina Wang, a former Ph.D student at Yale who is now at Harvard, is the other co-author. 
Read the press release on our website.
A Great Start To The 2015 Year-End Challenge Grant! 
Our year-end Fight Aging! challenge grant is off to a great start thanks to your generous support. Thank you to everyone who has donated so far. If you are considering making a contribution toward our work to end age-related disease, there is no better time than now. Remember that every dollar will be doubled thanks to the combined forces of:
Fight Aging!
Josh Triplett
Christophe and Dominique Cornuejols
Stefan Richter
We're delighted to be at $28,352 already after only two weeks since the challenge kicked off, but we need your help to reach our $125,000 goal! Visit sens.org/donate today.
Anyone interested in offering an additional challenge grant for Giving Tuesday – December 1st – please contact Jerri.Barrett@sens.org.
To donate go to www.sens.org/donate. 

RB2015 Keynote Videos Live On Website


The 2015 Rejuvenation Biotechnology Keynote address videos are now live on the SENS Research Foundation website.


Chas Bountra, SGC Oxford Chief Scientist, Professor of Translational Medicine, Nuffield Department of Clinical Medicine; Associate Member, Department of Pharmacology, University of Oxford, spoke on Transforming the Discovery of New Medicines. The keynote highlights society’s need to completely transform the manner in which new medicines are discovered. Bountra asserts that while patients want more novel, more effective, and more affordable medicines more quickly, the reality is that drug discovery today is too costly, too risky and too slow. To learn more, read our press release and view the video.



Frances Colón, Acting Science and Technology Advisor to the Secretary of State, United States Department of State, spoke on Science and Technology for Diplomacy. She explains the importance of advising political leaders in the areas of science and technology so they can make better, more informed decisions that lead to greater peace, stability and prosperity. To learn more read the press release and watch the video.


MitoSENS Mitochondrial Repair Project Crowdfunding Campaign Countdown:

9 Days Left To Reach Two New Goals


SRF is so grateful to everyone who helped the Mitochondrial Repair Project crowdfunding campaign reach - and exceed - our initial $30,000 goal so quickly.
The campaign isn't over yet, though, and your support during the final 9 days could make a huge positive impact by increasing the range of tools available to us to push this critical work forward. SRF's Dr. Matthew O'Connor elaborates on how via the lifespan.io campaign page:
"Hi everyone, thanks so much for your support in reaching our initial goal! I'm proud to announce that we have just received a donation from a local company in the form of a large quantity of free DNA primers. We used the donation to design a huge set of primers that we can use to make dozens more mitochondrial targeting sequences (MTSes) to test for their ability to target proteins to the mitochondria. So instead of the 3 that we've tested so far we could test many different ones that we suspect might be good candidates as stretch goals for this campaign.
If we reach a total of $45,000 we can test all of these MTSes on ATP6 and see if we can bring it up to full activity.
If we reach a total of $60,000 we can also test all of these targeting signals on a 3rd gene, Cytochrome B, which has long been a challenging gene for us and others in the field to make functional. If we can get this gene working, we should be able to make any gene in the system work.
In addition, we are excited to announce matching funds! Several of you have asked for this. For every dollar that you donate to the Mitochondrial Repair Project another dollar will go directly into the SENS Research Foundation general fund to support all the great research we do at SRF. Thanks to Reason at fightaging.org for helping to organize this fund to match your donations!"
Our campaign prizes still include a Mito Mech for players of the game Mecha Galaxy, a signed copy of Aubrey de Grey’s Ending Aging, and a dinner with Aubrey de Grey and television/movie star (and SRF fan) Edward James Olmos.
SENS Research Foundation Named a 2015 Top Rated Non Profit by GreatNonProfits.org
SENS Research Foundation has received ten 5-Star Reviews on GreatNonProfits.org. Thanks to all who took the time to review us - you've enabled us to be named a 2015 Top Rated Non-Profit!
GreatNonProfits.org is a Yelp-like review site for non-profit organizations that people can use to evaluate nonprofits while making donation decisions. They also distribute their list of top rated non-profits to potential donors. Please consider visiting GreatNonProfits.org and writing your own review of SENS Research Foundation - it's yet another way you can make a difference!

Methuselah Foundation Pledges $15K to Year End Fundraiser


SENS Research Foundation would like to thank the Methuselah Foundation for pledging $15,000 to the Fight Aging Fundraiser. Every dollar they donated was doubled by the challenge grant.



Please donate today and help us double your donation.

Where in the World is Aubrey de Grey This Month?
Where: Shenzen, China
When: October 22-25, 2015
ICG-10 will focus on recent breakthroughs and advancements in ‘omics’ research that will further transform scientific discoveries into better health, treatments and cures in the next decade. SRF CSO Aubrey de Grey will serve as chair and host the Q&A discussion for the Aging session to be held Saturday, October 24.
Where: European Solidarity Centre, Gdansk, Poland
When: October 27-28, 2015
This two-day event will serve as a platform for discussion of developmental challenges for Polish change-makers and their global counterparts. This year's conference will examine recent regional policy challenges, analyze key factors for the innovation ecosystem to thrive and identify necessary toolkits. Aubrey de Grey to present "Life Science: How To End Aging?" during "Trends in Innovation in Europe and the rest of the world" session, October 28, 2015, 10:20 AM.
Where: VDNH, Moscow, Pavillion 75, Russia
When: October 28 - November 1, 2015
Open Innovations Forum focuses on the creators of the current technological revolution, whose ideas and products stand to drastically change the main spheres of human life, global economy and social processes. High tech corporations, startups, venture industries, government officials, entrepreneurs and scientists, consumers and enablers of high tech solutions will meet in October in Moscow for this event. Dr. de Grey will give a free lecture on October 30, 2015, 7:00 PM at the Multimedia Art Museum as part of this event.

Upcoming Volunteer Fundraiser Events in California and Wisconsin To Benefit SRF


Fashion and Hope Fundraiser (Hosted by Kelly Martin)
When: October 23, 2015,  6:00 – 9:00 pm
Where: Urban Fuel
N7645 Peebles Lane,
Fond du Lac, WI
Volunteer Kelly Martin is hosting a fundraiser on Octobe-r 23rd called Fashion & Hope. The event will feature a fashion show, raffles and pashmina scarves for sale. Proceeds will be donated to support SENS Research Foundation, Kashmir World Foundation and Smile Train. Tickets are $20 and can be purchased at the door.  
For more information, call 920-602-5944.
Benefit Party for SRF (Hosted by Walter Crompton and Johnny Adams)
When: November 3, 2015,  6:30 – 9:00 pm
Where: 7 Mile House
2800 Bayshore Blvd
Brisbane, CA
SENS Research Foundation Volunteer Walter Crompton and Johnny Adams will be hosting a Benefit Party for SENS Research Foundation on November 3rd at the 7 Mile House in Brisbane, CA. The party will include dinner, a live band, and a silent auction. Aubrey de Grey will be there to meet and greet all the attendees. Space is limited to 30 people, so book your tickets now.
For more information and tickets please email Walter Crompton at walt@vivafina.com.
If you would like to host a fundraiser to benefit SRF, we are happy to help promote it. Just email jerri.barrett@sens.org.



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