November 13th 2018

November 13, 2018

SRF’s 2018 End of Year fundraiser is off to a great start thanks to our consistent donor base and the support of new donors joining our ranks. With the help of matching grants from IAS, Josh Triplett, Reason, and Christophe Cornuejols, we are making headway toward our goals. However, we do have a long way to go to reach $500,000 in our general fund by the new year. We’re also still looking for new SRF Patrons to help us unlock the $54,000 matching donation from Fight Aging!.

Our End of Year fundraiser is critical to funding the most cutting-edge work in rejuvenation biotechnology in the coming year, and we appreciate every donor and every dollar we receive to that end. Reimagine Aging with us and make your donation before December 31st to contribute to our vision of a world without age-related disease.

SRF 2018 Summer Scholars: Featuring The Next Generation of Rejuvenation Biotechnology Researchers (Part 3)

The SRF Summer Scholars Program offers undergraduate students the opportunity to conduct biomedical research to combat diseases of aging, such as cancer, Alzheimer's, and Parkinson's Disease. Under the guidance of a scientific mentor, each Summer Scholar is responsible for his or her own research project in such areas as genetic engineering and stem cell research. Follow along as we highlight the 2018 Summer Scholars with links to our Education blog for insights into their profiles and their important work in renowned laboratories.

PHOTO: From left - Lee Rao, Neha Ramchandani, Carolyn Barnes

This month's featured Summer Scholars are Lee Rao, Neha Ramchandani, and Carolyn Barnes, who conducted their projects respectively at the Scripps Research Institute, the Buck Institute for Research on Aging, and the SRF Research Center.

"Smart Bombs" Against Senescent Cells

A New Research Blog Article

By: Michael Rae

When Dr. de Grey and colleagues proposed ablation of senescent cells (apoptoSENS) as the “damage-repair” strategy of choice for this kind of aging damage in 2001,  you’d’ve been hard-pressed to find the idea even mentioned (let alone advocated) in the scientific literature — and certainly no one was actively working to develop such therapies. And this approach remained largely ignored until 2011, when a powerful proof-of-concept study showed that killing these “zombie cells” using a genetically-engineered “suicide switch” substantially rejuvenated a kind of mouse with a mutation that causes them to accumulate an abnormally high level of these cells.

Soon after that, the Mayo Clinic’s James Kirkland and colleagues developed an ingenious drug-discovery strategy that led to the identification of the first two of a new class of “senolytic” drugs — that is, drugs that selectively destroy senescent cells. Because of their stressful internal environment and the effects of their own secretions, such cells are highly dependent on specific biochemical survival pathways to prevent the activation of their inbuilt “cellular suicide” mechanisms. Senolytic drugs inhibit those pathways, tipping the balance in favor of self-destruction. 

In the three short years since that initial breakthrough, the progress in apoptoSENS has been astonishing.



Time To Get Your Tickets for Undoing Aging 2019!

SENS Research Foundation (SRF) and Forever Healthy Foundation (FHF) are delighted to host the second annual Undoing Aging conference, which will take place in Berlin at the Umspannwerk Alexanderplatz from March 28 to 30, 2019. Early Bird registration is still open for Undoing Aging 2019, so if you don't have your tickets yet, this would be a great time to make sure and secure your spot. After January 24, regular rates will apply, so buy soon to save €200.00. We look forward to seeing you there!

Where in the World is Aubrey de Grey?

Where: El Paso, TX, USA
When: November 16, 2018

Reset is the largest innovation and entrepreneurship event at the Mexico-United States border, where a series of conferences and workshops will be held by internationally renowned speakers. It is a meeting point to collaborate, create and learn through experiences designed to inspire young people in the region.

Where: Dublin, Ireland
When: November 19, 2018

Jointly Presented by the UCD Humanities Institute, UCD Centre for the History of Medicine in Ireland, UCD Conway Institute, UCD Institute for Discovery, UCD Geary Institute, and UCD HRB Ignite Connect Programme, this forum is part of an engagement series which aims to examine ageing as a complex phenomenon that requires a transdisciplinary frame of analysis. The goal is to adopt a constructive approach that analyses the biological, medical, psychological, social and cultural factors that can facilitate positive experiences of old age. 

Where: Paris, France
When: November 20, 2018

Festival of Ideas Paris explores a major societal challenge through interdisciplinary events that combine the Humanities and the Sciences, and that combine research and artistic creation.

What: Day One
Where: Monaco
When: November 29, 2018

Designed for changemakers and organizations that value a global conversation and are the first to take action, Day One is the place for visionary leaders to participate in global debates and drive towards concrete decisions that will make the world a better place. Over the course of 2.5 days in Monaco (28-30 November) we will challenge each other to forge an inclusive vision of the world with humanity at the center.

Where: Buck Institute of Research on Aging, Novato, CA, USA
When: December 3, 2018

In 1988, a seminal observation was made in the genetics of aging. Aging was not inevitable. Using a simple model organism, the nematode worm C. elegans, scientists discovered that aging was plastic, and lifespan could be extended and manipulated using the genetic tools of the time. This breakthrough rippled throughout the scientific community, creating the foundation upon which the modern field of Geroscience was built. It’s been 30 years since this “golden age” of the genetics of aging, and the scientific community is poised to begin clinical trials targeting both diseases of aging and aging itself, based on fundamental observations generated over the last three decades. Please join us on December 3rd, 2018 at the Buck Institute for Research on Aging, where we will celebrate both the exciting discoveries which have driven the modern field of Geroscience, as well as a peek into the not too distant future.

Please show your support for SRF's work - Donate Today

As a 501(c)(3) public charity, SENS Research Foundation relies on your support to continue our mission to change the way the world researches and treats age-related disease.


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