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Targeted exosome coating gene-chem nanocomplex as "nanoscavenger" for clearing α-synuclein and immune activation of Parkinson's disease
Linying Liu 1 2 3, Yan Li 1 2, Huan Peng 1 2, Ruiyuan Liu 1 2, Weihong Ji 1 2, Zhuyan Shi 1 2, Jie Shen 1 2, Guanghui Ma 1, Xin Zhang 4 2
Abstract:
...Here, we show an engineering core-shell hybrid system named rabies virus glycoprotein (RVG) peptide-modified exosome (EXO) curcumin/phenylboronic acid-poly(2-(dimethylamino)ethyl acrylate) nanoparticle/small interfering RNA targeting SNCA (REXO-C/ANP/S). It is a nanoscavenger for clearing α-synuclein aggregates and reducing their cytotoxicity in Parkinson's disease neurons. The motor behavior of Parkinson's disease mice is substantially improved after REXO-C/ANP/S treatment. In particular, we demonstrate that REXO-C/ANP/S is also a nanoscavenger for clearing immune activation due to its natural immature dendritic cell EXO coating. Our findings show that REXO-C/ANP/S may serve as a platform for neurodegenerative diseases treatment.
PMID: 33310840
Free Full-Text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732192/
