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SMER28 binding to VCP/p97 enhances both autophagic and proteasomal neurotoxic protein clearance
Autophagy. 2022 Aug 28;1-3. doi: 10.1080/15548627.2022.2116832.
Lidia Wrobel 1 2, Sandra M Hill 1 2 3, David C Rubinsztein 1 2
Abstract:
...We recently found that targeting VCP/p97 with compounds like SMER28 enhances macroautophagy/autophagy flux mediated by the increased activity of the PtdIns3K complex I. Additionally, we found that SMER28 binding to VCP stimulates aggregate-prone protein clearance via the ubiquitin-proteasome system. This concurrent action of SMER28 on both degradation pathways resulted in the selective decrease in disease-causing proteins but not their wild-type counterparts...
PMID: 36036202
Tags: autophagy, p97, Protein aggregate removal, protein aggregates, SMER28, VCP