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Molecular mechanism for the red blood cell senescence clock.
IUBMB Life. 2018 Jan;70(1):32-40. doi: 10.1002/iub.1703
Badior KE, Casey JR
Abstract:
Lacking protein synthesis machinery and organelles necessary for autophagy or apoptosis, aged red blood cells (RBCs) are marked by circulating auto-antibodies for macrophage-mediated clearance. The antigen recognized by these auto-antibodies is the major protein of the RBC membrane, Band 3. To ensure regulation and specificity in clearance, the molecular "clock" must mark senescent cells in a way that differentiates them from younger cells, to prevent premature clearance. Predominant models of Band 3 senescence signaling are reviewed, and merits are discussed in light of the recently published crystal structure of the Band 3 membrane domain.
PMID: 29240292
Free Full-Text: https://iubmb.onlinelibrary.wiley.com/doi/full/10.1002/iub.1703