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Mitochondrial Transplantation Enhances Phagocytic Function and Decreases Lipid Accumulation in Foam Cell Macrophages
Biomedicines. 2022 Jan 30;10(2):329. doi: 10.3390/biomedicines10020329.
Soraya Játiva 1, Priscila Calle 1 2, Selene Torrico 1, Ángeles Muñoz 3, Miriam García 1, Ivet Martinez 3, Anna Sola 4, Georgina Hotter 3 5
Abstract:
...We aimed to prove that the transplantation of healthy mitochondria to highly cholesterol-loaded macrophages induces macrophage phagocytosis and reduces the macrophage shift towards foam cells. For this purpose, using a murine macrophage cell line, RAW264.7, we determined if mitochondria transplantation to 7-ketocholesterol (7-KC)-loaded macrophages reduced lipid accumulation and modified their phagocytic function. We evidenced that mitochondrial transplantation to 7-KC-loaded macrophages reestablished phagocytosis and reduced lipid content. In addition, CPT1a expression and anti-inflammatory cytokines were restored after mitochondrial transplantation. We have developed a potential therapeutic approach to restore foam cell functionality.
PMID: 35203538
Free Full-Text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8869430/