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Infections, Vaccinations, and Risk of Alzheimer's Disease (AD)/Dementia: Probable Involvement of Reactivated Herpes Simplex Virus Type 1
Ruth F Itzhaki 1
Abstract:
Infections are associated with cognitive decline and increased risk of AD/dementia, and some studies have shown that vaccinations, such as BCG, against a variety of infections decrease the risk. Several reports have described an association of varicella zoster virus (VZV) with AD, and in an epidemiological study, we found that shingles, a disease caused by VZV, conferred a small increased AD/dementia risk, while vaccination against the disease led to a greatly decreased risk - subsequently confirmed by others
