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Fucoidan reduces lipid accumulation by promoting foam cell autophagy via TFEB
Carbohydr Polym. 2021 Sep 15;268:118247. doi: 10.1016/j.carbpol.2021.118247.
Jiarui Zhao 1, Bo Hu 2, Han Xiao 3, Qiong Yang 4, Qi Cao 5, Xia Li 6, Qian Zhang 7, Aiguo Ji 8, Shuliang Song 9
Abstract:
...As a sulfated polysaccharide with anti-inflammatory and hypolipidemic activities, fucoidan can induce autophagy. We show here that fucoidan reduces lipid accumulation in foam cells, which is one of the causes of atherosclerosis. Further studies show that fucoidan promotes autophagy showed by the expression of p62/SQSTM1 and microtubule-associated protein light chain 3 (LC3) II, which can be blocked by autophagy inhibitors 3-MA and bafilomycin A1. In addition, the expression of transcription factor EB (TFEB), master regulator of autophagy and lysosome function, is upregulated after the treatment with fucoidan. Moreover, the knockout of TFEB with small interfering RNA suppressed the effect of fucoidan. Together, fucoidan reduces lipid accumulation in foam cells by enhancing autophagy through the upregulation of TFEB. In view of the role of foam cells in atherosclerosis, fucoidan can be valuable for the treatment of atherosclerosis.
PMID: 34127226
Tags: atherosclerosis, autophagy, foam cells, Fucoidan, TFEB