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Commentary on Some Recent Theses Relevant to Combating Aging: October 2020
Rejuvenation Res. 2020 Oct;23(5):439-445. doi: 10.1089/rej.2020.2391.
Benjamin Zealley, Aubrey D N J de Grey
Abstract:
Theses reviewed in this issue include "Engineering Efficient and Safe In Situ Genome Regulation via CRISPR-Cas9 for Enabling Gene Therapies," "Investigating the Mechanism of LINE-1 Retrotransposition in Human Cells," "Machine Learning Approaches for Prediction of Kidney Transplant Survival," "Novel Obesity Suppressor Function of the Retinoblastoma Protein Uncovers Cyclin-Dependent Kinase 4 as a Therapeutic Target for Diet-Induced Obesity," "Regeneration of Retinal Neurons from Müller Glia in Adult Mice," and "Reprogramming T Cells to Interrogate Intracellular Disease Signatures."
PMID: 32977731
Tags: CRISPR-Cas9, LINE-1, obesity, retina, T cells