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Cerebral amyloid angiopathy interacts with neuritic amyloid plaques to promote tau and cognitive decline
Jennifer S Rabin 1 2 3, Emma Nichols 4, Renaud La Joie 5, Kaitlin B Casaletto 5, Priya Palta 6, Kristen Dams-O'Connor 7 8, Raj G Kumar 7, Kristen M George 9, Claudia L Satizabal 10 11, Julie A Schneider 12, Judy Pa 13, Adam M Brickman 14
Abstract:
...In the present study, we examined whether cerebral amyloid angiopathy influences tau deposition and cognitive decline independently or synergistically with parenchymal β-amyloid burden. Secondly, we examined whether tau burden mediates the association between cerebral amyloid angiopathy and cognitive decline...The study sample included 1722 autopsied subjects (age at baseline = 80.2 ± 7.1 years; age at death = 89.5 ± 6.7 years; 68% females). Cerebral amyloid angiopathy interacted with neuritic plaques to accelerate tau burden and cognitive decline. Specifically, those with more severe cerebral amyloid angiopathy pathology and higher levels of neuritic plaque burden had greater tau burden and faster cognitive decline. We also found that tau mediated the association between cerebral amyloid angiopathy and cognitive decline among participants with higher neuritic plaque burden...
