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Ageing of the B-cell repertoire.
Philos Trans R Soc Lond B Biol Sci. 2015 Sep 5;370(1676). pii: 20140237. doi: 10.1098/rstb.2014.0237
Martin V, Bryan Wu YC, Kipling D, Dunn-Walters D
Abstract:
.....In this paper, we present an analysis of immunoglobulin repertoire in different subclasses of antibody in five different populations of B cell, and show how the repertoire in these different groups changes with age. Although some age-related repertoire differences occur in naive cells, before exogenous antigen exposure, we see indications that there is a general dysregulation of the selective forces that shape memory B-cell populations in older people.
PMID: 26194751
Tags: B cells, humans, immune senescence