SENS PubMed Publication Search
The Role of the Microenvironmental Niche in Declining Stem-Cell Functions Associated with Biological Aging.
DeCarolis NA, Kirby ED, Wyss-Coray T, Palmer TD
Abstract:
.....This article focuses on new insights gained through the use of heterochronic parabiosis models, in which an old mouse and a young circulatory system are joined. By studying the brains of both young and old mice, researchers are beginning to uncover circulating proneurogenic "youthful" factors and "aging" factors that decrease stem-cell activity and neurogenesis. Ultimately, the identification of factors that influence stem-cell aging may lead to strategies that slow or even reverse age-related decreases in neural-stem-cell (NSC) function and neurogenesis.
