External News Archive

New synthetic offers a better glimpse into diabetes and the aging process

"A synthetic process developed at Yale University will allow researchers to study a key molecule involved in diabetes, inflammation, and human aging.

The new process synthesizes glucosepane, which is considered a critical chemical link in both diabetes and aging. It is also an independent risk factor for long-term microvascular complications in diabetes.

In a study published this week in the journal Science, senior author David Spiegel and his colleagues describe the new synthesis, as well as a new synthetic methodology, which may have applications beyond the current research."

Read More at New synthetic offers a better glimpse into diabetes and the aging process.

The End of Life and Death

"In this exclusive interview series, we speak to Prof. Jack Szostak (Nobel Prize winning Geneticist), Dmitry Itskov (billionaire founder of the 2045 Initiative), Aubrey de Grey (Chief Science Officer of the SENS Research Foundation), Prof. Ezekiel Emanuel (Bioethicist and Fellow at the Centre for American Progress) and Prof. George Church (Professor of Genetics at Harvard Medical School). We discuss the fundamental essence of life itself, why we die, research into extending lifespans, and whether we will ever overcome our mortality."

Read More at The End of Life and Death.

TED Radio Hour: The Fountain Of Youth

"Aging is inevitable. We can slow it down a little, but could we ever bring it to a grinding halt? In this episode, TED speakers explore how we all might live longer and even better lives."

Read More at TED Radio Hour: The Fountain Of Youth.

Companies go long by investing in longevity

"A dizzying number of research institutes, wealthy entrepreneurs and companies, including Google Inc., are investing in research and treatments aimed at creating an ostensible fountain of youth."

Read More at Companies go long by investing in longevity.

Silicon Valley invests in fix-all cure to growing old

"Silicon Valley technologists are trying to find a cure for ageing. Billionaires like Oracle founder Larry Ellison have talked of accepting death as incomprehensible and companies like Google have invested in start-ups seeking to use technology to enhance lifespan. Learn more about one foundation that has received sizable investments from tech moguls looking to keep bodies from breaking down."

Read More at Silicon Valley invests in fix-all cure to growing old.

Front and Center: Singer, Composer, Pilot, Global Outreach Coordinator at SENS Research Foundation, Maria Entraigues-Abramson

"L.A.-based singer, composer, pilot and SENS Research Foundation Outreach Coordinator Maria Entraigues-Abramson is a force to be reckoned with.

Armed with a hauntingly beautiful voice, a commanding presence, and a skill set as broad as the skies she flies as a private pilot, Entraigues-Abramson has graced audiences all over the world with her voice, performing with acts ranging from Latin icon Ricky Martin to Japanese superstar Eikichi Yazawa.

Originally from Argentina, Entraigues-Abramsom graduated from Berklee College of Music Graduate and established a solid reputation working with the biggest movie producers composing music for films.

She is fascinated by science and currently serves as the outreach coordinator for SENS Research Foundation, a non-profit organization located in the Bay Area working to develop new therapies to prevent, reverse and eradicate the diseases of aging."

Read More at Front and Center: Singer, Composer, Pilot, Global Outreach Coordinator at SENS Research Foundation, Maria Entraigues-Abramson.

Will Anti-Aging Drugs Lead To A Brave New World?

"Ponce de León’s Fountain of Youth may soon be more than just a myth. According to Aubrey de Grey, a leading anti-aging researcher, there is likely a person alive today who will be immune to aging.  This optimism stems from the promising field of longevity research, which has shed its reputation as a quackery-ridden fringe science. If clinical trials of anti-aging drugs prove successful, it would utterly transform society in far-reaching ways. Could today’s generations live to see a world where 100 is the new 60?"

Read More at Will Anti-Aging Drugs Lead To A Brave New World?.

The Joe Rogan Experience: Aubrey de Grey

SENS Research Foundation's Chief Science Officer, Dr. Aubrey de Grey, was recently interviewed regarding our work for the Joe Rogan Experience podcast.

Read More at JRE #638 - Aubrey de Grey.

Will Humans Ever Live 200 Years?

"When 116-year-old Gertrude Weaver died of pneumonia this week in Arkansas, she had held the title of world’s oldest person for all of five days. And she was still a bit younger than 122-year-old Frenchwoman Jeanne Calment, who passed away in 1979 and holds the record for oldest human...

Futurists like Aubrey DeGrey have said that eliminating just a few diseases and coming up with new treatments for aging could lead to 1,000-year-old humans. DeGrey, who has been pushing his ideas on rejuvenation and life-extension, has gotten some deep-pocketed company in the past year."

Read More at Will Humans Ever Live 200 Years?.

European Insurance Forum details announced

"The event has a line-up of over 40 speakers, including some of the world’s leading experts and commentators in their respective fields, who will examine and discuss the growing global challenges facing the re/insurance and captive industry and in particular its impact on managing risk.

Among the speakers secured for the event is Dr Aubrey de Grey, chief science officer at SENS Research Foundation and Prof Ian Goldin, professor of globalisation and development and director of the Oxford Martin School at the University of Oxford."

Read More at European Insurance Forum details announced.

Tech titans' latest project: Defy death

"For centuries, explorers have searched the world for the fountain of youth. Today’s billionaires believe they can create it, using technology and data."

Read More at Tech titans’ latest project: Defy death.

Control ALT, Delete Cancer

"Cellular immortality is a hallmark of cancers that distinguishes them from normal tissue. Every time a normal somatic cell divides, the DNA at the ends of its chromosomes, called the telomeres, gets shorter. When the telomeres shorten too much, an alarm signal is generated, and the cell permanently stops dividing and enters senescence or undergoes apoptosis. Telomere shortening thus acts as a biological mechanism for limiting cellular life span.  Cancer cells, on the other hand, can become immortalized by activating a telomere maintenance mechanism (TMM) that counteracts telomere shortening by synthesizing new telomeric DNA from either an RNA template using the enzyme telomerase or a DNA template using a mechanism called alternative lengthening of telomeres (ALT)."

Read More at Control ALT, Delete Cancer.

A Long Interview with Aubrey de Grey on London Real

"Aubrey de Grey is a true frontiersman, daring to push out against what seems the most natural and unstoppable forces of nature - ageing. He's not just another voice though, he's a scientist and identifies ageing as a disease, one that can be cured with the right medicine. His work calls for serious scientific exploration of what causes tissue to age and to then find solutions to those components - what he calls the roadmap to defeat biological ageing. In fact, he believes that the first humans who will live to be 1,000 years old are already alive today!"

Read More at A Long Interview with Aubrey de Grey on London Real.

Silicon Valley Is Trying to Make Humans Immortal—and Finding Some Success

"Peter Thiel, the billionaire co-founder of PayPal, plans to live to be 120. Compared with some other tech billionaires, he doesn’t seem particularly ambitious. Dmitry Itskov, the “godfather” of the Russian Internet, says his goal is to live to 10,000; Larry Ellison, co-founder of Oracle, finds the notion of accepting mortality “incomprehensible,” and Sergey Brin, co-founder of Google, hopes to someday “cure death.”

These titans of tech aren’t being ridiculous, or even vainglorious; their quests are based on real, emerging science that could fundamentally change what we know about life and about death."

Read More at Silicon Valley Is Trying to Make Humans Immortal—and Finding Some Success.

Are We Hunting Longevity In All The Wrong Places?

"Death—that was so last century. Here in the early 21st, it’s all about life. More life. A lot more life.

Right now, anti-aging medicine is booming. For certain, the size of the market is a little hard to determine, but most estimates put it close to $300 billion. And growing.

Already, serious heavyweights like Google and Human Longevity Inc. (HLI)—the company founded by X Prize founder Peter Diamandis, stem-cell pioneer Robert Hariri, and genomics visionary Craig Venter—have entered the fray. And, of course, ideas about slowing the insults of time are everywhere."

Read More at Are We Hunting Longevity In All The Wrong Places?.

To These Foundations, Aging is the Enemy

"You already know that, as we grow older, we become more prone to many kinds of ailments: cancers, heart disease, dementia, and others. Any number of private foundations are sponsoring research targeting one or more of these age-related conditions. Less common, though, are foundations that are taking on the aging process itself.

The Larry Ellison Medical Foundation used to be a leader in this area, but pulled the plug on such research in late 2013...

But Ellison was never alone in his "war on death." And two funders still searching for a modern-day fountain of youth are the Methuselah Foundation and the SENS Research Foundation. Indeed, they are partnering on finding treatments that basically make older people young again. "

Read More at To These Foundations, Aging is the Enemy.

A Framework to Increase Longevity and End Aging

"Longevity is a subject close to my heart, and I’ve been following the career of today’s guest for many years. Dr. Aubrey de Grey is a visionary and general strategist in the field of gerontology who applies the concepts of planning, investment, and risk management to the science of aging. With his strategic approach, he’s created the seven “Strategies for Engineered Negligible Senescence” that offer a practical route to longer life.

Dr. de Grey may be the greatest activist for longevity of our time. He’s the Chief Science Officer for the SENS Research Foundation, a not-for-profit organization funding research into longevity around the world. He’s authored two books; Ending Aging: The Rejuvenation Breakthroughs that Could Reverse Human Aging in our Lifetime in 2008 and The Mitochondrial Free-Radical Theory of Aging, for which he received his PhD in 1999.

In today’s interview we examine popular longevity strategies such as caloric restriction and telomerase therapies, as well as those stemming from his research. His contrasting viewpoints offer insight compared to what you might see in the press."

Read More at A Framework to Increase Longevity and End Aging.

SENS Research Foundation Now Accepts Bitcoin Donations

"SENS Research Foundation is one of the few organizations persistently finding ways to move the needle, to speed things up, to bring more attention to the field. The scope of success here is at present only limited by funding: there are any number of scientists in the aging research community who would drop their present work in favor of SENS biotechnology to treat aging given the budget.

With that in mind, here is a little news for those who might have a few bitcoins left over after all the excitement of the past eighteen months or so..."

Read More at SENS Research Foundation Now Accepts Bitcoin Donations.

Living to 150 is the new holy grail

"Age defiance is a staggeringly lucrative ­industry. Last year the global anti-ageing ­market generated more than $280 billion. By 2018 it will hit $400 billion. A new tribe is ­taking advantage of sophisticated scientific breakthroughs... this appears to be only the beginning of the new age of ageing. It’s little wonder that the latest venture from Google, the most successful innovator on the planet, is ageing-related. Mere cosmetic enhancements are child’s play to Google, which is on an altogether more ambitious trajectory...

Larry Ellison, CEO of the computer tech company Oracle and the fifth wealthiest man in the world, according to Forbes magazine, is the money behind the ­Ellison ­Medical Foundation, an anti-ageing biomedical research centre. The Californian venture capitalist Paul F. Glenn has endowed hundreds of ­millions to life-expansion research at Ivy League institutions such as Harvard, Princeton, MIT and Stanford. Peter Thiel, co-founder of PayPal and a Facebook board member, is a ­supporter of SENS, a research foundation ­specialising in rejuvenation treatments.

SENS is run by Aubrey de Grey, a British ­gerontologist who believes that the first person to live to 150 is already alive today – a view shared by federal treasurer Joe Hockey, who was ridiculed recently for making this exact claim while arguing the case for budget cuts.

“Rejuvenation biotechnologies are, very ­simply, medicines that restore the structure of the body to how it was in early adulthood, and thereby restore it to maximum physical and mental performance,” explains de Grey, who also co-founded the Methuselah – a foundation whose aim, through tissue engineering and regenerative medicine, is to create a world by 2030 in which 90-year-olds can be as healthy as 50-year-olds. “By restoring the molecular and cellular structure of the body to that of a young adult, we will necessarily restore its function, too, which constitutes reversing ageing. Thus, ­people will remain truly healthy for longer, postponing the ill health that inescapably accompanies old age today.”"

Read More at Living to 150 is the new holy grail.

Exponential Medicine and Digital Healthcare

"Most people know that healthcare has rapidly become an information technology and health and medicine is changing exponentially.Just as technology is democratizing all aspects of life, no field is being disrupted more quickly than healthcare and the implications of digital will bring a trillion dollars worth of disruption to outdated diagnosis, treatment and delivery of healthcare. Moreover, the human race will live long enough soon to live forever as nanotechnology, robotics, Gene sequencing and AI cure age old problems."

Interview with SRF CSO Dr. Aubrey de Grey, Dr. Dan Barry, and Vinod Khosla.

Read More at Exponential Medicine and Digital Healthcare.